NMR STUDIES OF CHROMOMYCINS, OLIVOMYCINS, AND THEIR DERIVATIVES

Abstract

Detailed studies on the ¹³C and ¹H NMR spectra of chromomycins A₂ and A₃, olivomycins A and B, and their derivatives clarified the assignment of many signals which had been unassigned or erroneously reported in the literatures. The revised assignments for chromomycin A₃ and olivomycin A include the assignment of a key ¹³C signal used to discuss the saccharide linkage in question. Structure analyses based on the revised assignments support the α, 1→3-bond between components of the disaccharide moiety in the molecules. Some general information useful for structure analysis of saccharides is also reported.