The Journal of Antibiotics
LYSOBACTIN, A NOVEL ANTIBACTERIAL AGENT PRODUCED BY LYSOBACTER SP.
II. BIOLOGICAL PROPERTIES
DANIEL P. BONNERJOSEPH O'SULLIVANS. KEN TANAKAJUNIUS M. CLARKRITA R. WHITNEY
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JOURNALS FREE ACCESS

Volume 41 (1988) Issue 12 Pages 1745-1751

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Abstract

Lysobactin, an antibiotic isolated from a strain of Lysobacter, is 2 to 4-fold more active than vancomycin against aerobic and anaerobic Gram-positive bacteria. Included in the spectrum of lysobactin are Staphylococci, Streptococci, corynebacteria, clostridia and various other Gram-positive anaerobic bacteria. The activity of lysobactin against aerobic and anaerobic Gram-negative bacteria is poor. When given parenterally the compound was efficacious in systemic staphylococcal and streptococcal infections in mice. Similarly, when applied topically lysobactin was also curative in a staphylococcal wound infection in mice. Some studies on the mode of action of lysobactin are presented.

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