The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ANTIBIOTICS FROM BASIDIOMYCETES. XXIX: PILATIN, A NEW ANTIBIOTICALLY ACTIVE MARASMANE DERIVATIVE FROM CULTURES OF FLAGELLOSCYPHA PILATII AGERER
J. HEIMT. ANKEU. MOCEKB. STEFFANW. STEGLICH
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JOURNALS FREE ACCESS

1988 Volume 41 Issue 12 Pages 1752-1757

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Abstract

Pilatin, a new marasmane derivative, was isolated from fermentations of the cyphelloid fungus Flagelloscypha pilatii. Its structure was determined by chemical and physical methods. Pilatin inhibits the growth of bacteria and fungi at concentrations of 5-50μg/ml. The compound is highly cytotoxic. The incorporation of thymidine and uridine into DNA and RNA in Ehrlich carcinoma ascitic cells is strongly inhibited by pilatin. Like marasmic acid pilatin causes frameshift mutations in Salmonella typhimurium TA 98.

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