NOVEL MACROCYCLIC ANTIBIOTICS: MEGOVALICINS A, B, C, D, G AND H

I. SCREENING OF ANTIBIOTICS-PRODUCING MYXOBACTERIA AND PRODUCTION OF MEGOVALICINS

Abstract

New antibiotics belonging to macrocyclic were discovered and named megovalicins A, B, C, D, G and H. The antibiotics were accumulated endogeneously by a newly isolated myxobacterium identified as Myxococcus flavescens. Tank culture of the bacterium for 4 days gave 8.8 g cells/liter on a wet basis, and 4, 8, 7.1, 20.0, 0.4, 3.75 and 15.0 μg of megovalicins A, B, C, D, G and H respectively were obtained from 1 g wet cells.