The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
A83586C, A NEW DEPSIPEPTIDE ANTIBIOTIC
TIM A. SMITKA, JACK B. DEETER, ANN H. HUNT, FREDERICK P. MERTZ, ROBERT M. ELLIS, LAVERNE D. BOECK, RAYMOND C. YAO
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1988 Volume 41 Issue 6 Pages 726-733

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Abstract
A culture identified as Streptomyces karnatakensis was found to produce a novel cyclic hexadepsipeptide antibiotic designated A83586C. The structure was elucidated by X-ray crystallography, and full 1H and 13C NMR assignments are reported. The absolute configuration was confirmed by the detection of D-threonine in the acid hydrolysate of A83586C. A83586C had potent Gram-positive activity in vitro but lacked in vivo efficacy in mice.
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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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