BMY-28438 (3, 7-DIHYDROXYTROPOLONE), A NEW ANTITUMOR ANTIBIOTIC ACTIVE AGAINST B16 MELANOMA I. PRODUCTION, ISOLATION, STRUCTURE AND BIOLOGICAL ACTIVITY

KOKO SUGAWARA; MASARU OHBAYASHI; KEIKO SHIMIZU; MASAMI HATORI; HIDEO KAMEI; MASATAKA KONISHI; TOSHIKAZU OKI; HIROSHI KAWAGUCHI

doi:10.7164/antibiotics.41.862

BMY-28438 (3, 7-DIHYDROXYTROPOLONE), A NEW ANTITUMOR ANTIBIOTIC ACTIVE AGAINST B16 MELANOMA

I. PRODUCTION, ISOLATION, STRUCTURE AND BIOLOGICAL ACTIVITY

KOKO SUGAWARA, MASARU OHBAYASHI, KEIKO SHIMIZU, MASAMI HATORI, HIDEO KAMEI, MASATAKA KONISHI, TOSHIKAZU OKI, HIROSHI KAWAGUCHI

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JOURNAL FREE ACCESS

1988 Volume 41 Issue 7 Pages 862-868

DOI https://doi.org/10.7164/antibiotics.41.862

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Abstract

A new antitumor antibiotic BMY-28438 was isolated from the cultured broth of Streptomyces tropolofadens No. K611-97. The antibiotic showed potent cytotoxicity against cultured B16 melanoma cells and remarkable prolongation of life span of mice bearing B16 melanoma. The structure of BMY-28438 was determined as 3, 7-dihydroxytropolone on the basis of spectral analyses and direct comparison with the authentic compound synthesized.

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