BENADROSTIN, NEW INHIBITOR OF POLY(ADP-RIBOSE) SYNTHETASE, PRODUCED BY ACTINOMYCETES I. TAXONOMY, PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES

TAKAAKI AOYAGI; SHIGEMI YOSHIDA; SHIGEKO HARADA; AKIRA OKUYAMA; CHIEKO NAKAYAMA; TAMAMI YOSHIDA; MASA HAMADA; TOMIO TAKEUCHI; HAMAO UMEZAWA

doi:10.7164/antibiotics.41.1009

BENADROSTIN, NEW INHIBITOR OF POLY(ADP-RIBOSE) SYNTHETASE, PRODUCED BY ACTINOMYCETES

I. TAXONOMY, PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES

TAKAAKI AOYAGI, SHIGEMI YOSHIDA, SHIGEKO HARADA, AKIRA OKUYAMA, CHIEKO NAKAYAMA, TAMAMI YOSHIDA, MASA HAMADA, TOMIO TAKEUCHI, HAMAO UMEZAWA

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JOURNAL FREE ACCESS

1988 Volume 41 Issue 8 Pages 1009-1014

DOI https://doi.org/10.7164/antibiotics.41.1009

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Abstract

Benadrostin, a new inhibitor of poly(ADP-ribose) synthetase was discovered in the fermentation broth of Streptomyces flavovirens MH499-O'F1. It was purified by chromatography followed by solvent extraction and then isolated as colorless prisms. Benadrostin has the molecular formula of C₈H₅NO₄. It was competitive with the substrate, and the inhibition constant (Ki) was 34 μM.

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