The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
METABOLIC PRODUCTS OF MICROORGANISMS. 249
TETRACENOMYCINS B3 AND D3, KEY INTERMEDIATES OF THE ELLORAMYCIN AND TETRACENOMYCIN C BIOSYNTHESIS
JURGEN ROHRSUSANNE EICKAXEL ZEECKPETER REUSCHENBACHHANS ZÄHNERHANS-PETER FIEDLER
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1988 Volume 41 Issue 8 Pages 1066-1073

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Abstract

Tetracenomycins B3 and D3, besides tetracenomycin D (D1), were produced by a blocked mutant of the elloramycin producer Streptomyces olivaceus TÜ 2353. The compounds were isolated as red powders, and their structures were elucidated by comparing their physicochemical data with those of the known tetracenomycins A2, B1, B2, D and E. Tetracenomycin B3 (2), the main compound, and tetracenomycin D (3) were antibiotically inactive against Gram-positive and Gram-negative bacteria, whereas tetracenomycin D3 (1) showed a moderate activity against Bacillus subtilis and Arthrobacter aurescens. Tetracenomycin B3 (2) is the key intermediate where the biosynthesis of the elloramycins branches off from the line leading to tetracenomycin C (5) as the final product of the tetracenomycin biosynthesis branch.

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