ISOLATION AND CHARACTERIZATION OF NEW ANTIBIOTICS RESORCINOMYCINS A AND B

Abstract

New antibiotics, resorcinomycins A and B, were isolated from the culture broth of a streptomycete strain identified as Streptoverticillium roseovertidllatum. The antibiotics are water-soluble amphoteric substances, positive to SAKAGUCHI'S reagent. The molecular formulas C₁₄H₂₀N₄O₅ and C₁₃H₁₈N₄O₅ for A and B were indicated by elemental analysis and secondary ion MS. The structures of these antibiotics were determined by ¹H and ¹³C NMR spectrometry and some chemical evidences to be N-[(S)-α-guanidino-3, 5-dihydroxy-4-isopropylphenylacetyl]glycine and N- [(S) - α - guanidino -3, 5-dihydroxy -4-ethylphenylacetyl]glycine, respectively.