ENDUSAMYCIN, A NOVEL POLYCYCLIC ETHER ANTIBIOTIC PRODUCED BY A STRAIN OF STREPTOMYCES ENDUS SUBSP. AUREUS

Abstract

Endusamycin formerly called CP-63, 517 (C₄₇H₇₇O₁₄Na), is a novel polycyclic ether antibiotic produced by a new strain of Streptomyces endus subsp. aureus (ATCC 39574). Recovery, fractionation and purification were achieved using standard procedures. Forms include the endusamycin free acid, mp 95 - 105°C, λ_max 232 nm (log E 4.16), [α]²⁵_D +47.4° (c 0.5, methanol) and a crystalline sodium salt, mp 215-220°C, λ_max 232 nm, (log E 4.15), [α]²⁵_D +25° (c 0.5, methanol). The structure is shown below, Fig. 1. Endusamycin exhibited; antibacterial activity, in vitro against Gram-positive and anaerobic bacteria, effectiveness against coccidia in poultry, and stimulation of propionic acid production in an in vitro system.