NOVEL CYTOCIDAL ANTIBIOTICS, GLUCOPIERICIDINOLS A₁ AND A₂

TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL CHARACTERISTICS

Abstract

Two novel antibiotics, glucopiericidinols A₁ (1) and A₂ (2) were isolated from the cultured broth of Streptomyces sp. OM-5689. The structures of these two compounds were deduced employing spectroscopic analyses. These antibiotics showed potent cytocidal activities against HeLa S₃ cells in vitro (MIC 1: 0.39μg/ml, 2: 0.10μg/ml) when the cells were exposed to the antibiotics for 3 days. Although 1 and 2 showed no activity at 1, 000 μg/ml against various Gram-positive and Gram-negative bacteria, yeast or fungi, they did have inhibitory activity against Piricularia oryzae (MIC of 1: 125μg/ml, of 2: 31μg/ml).