CALICHEAMICINS, A NOVEL FAMILY OF ANTITUMOR ANTIBIOTICS: TAXONOMY, FERMENTATION AND BIOLOGICAL PROPERTIES

W. M. MAIESE; M. P. LECHEVALIER; H. A. LECHEVALIER; J. KORSHALLA; N. KUCK; A. FANTINI; M. J. WILDEY; J. THOMAS; M. GREENSTEIN

doi:10.7164/antibiotics.42.558

W. M. MAIESE, M. P. LECHEVALIER, H. A. LECHEVALIER, J. KORSHALLA, N. KUCK, A. FANTINI, M. J. WILDEY, J. THOMAS, M. GREENSTEIN

Author information

JOURNAL FREE ACCESS

1989 Volume 42 Issue 4 Pages 558-563

DOI https://doi.org/10.7164/antibiotics.42.558

Details

Abstract

A novel family of antitumor antibiotics, the calicheamicins, were isolated from the fermentation broth of Micromonospora echinospora subsp. calichensis. These antibiotics exhibited significant activity against Gram-positive and Gram-negative bacteria in vitro. Calicheamicin γ₁^I demonstrated antitumor activity against P388 leukemia and B16 melanoma in vivo.

Corresponding author

Register with J-STAGE for free!