CHEMICAL MODIFICATION OF HITACHIMYCIN II. SYNTHESIS AND ANTITUMOR ACTIVITIES OF CARBONATE DERIVATIVES

KIYOSHI SHIBATA; SADAYOSHI SATSUMABAYASHI; HIROSHI SANO; KANKI KOMIYAMA; YANG ZHI-Bon; AKIRA NAKAGAWA; SATOSHI OMURA

doi:10.7164/antibiotics.42.718

CHEMICAL MODIFICATION OF HITACHIMYCIN

II. SYNTHESIS AND ANTITUMOR ACTIVITIES OF CARBONATE DERIVATIVES

KIYOSHI SHIBATA, SADAYOSHI SATSUMABAYASHI, HIROSHI SANO, KANKI KOMIYAMA, YANG ZHI-Bon, AKIRA NAKAGAWA, SATOSHI OMURA

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JOURNAL FREE ACCESS

1989 Volume 42 Issue 5 Pages 718-726

DOI https://doi.org/10.7164/antibiotics.42.718

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Abstract

Several carbonate derivatives of hitachimycin have been synthesized and evaluated their activities including antibacterial, cytocidal against HeLa cells and in vivo antitumor against Sarcoma 180. Some of these derivatives showed higher antitumor activity than hitachimycin. Among the derivatives, 11, 15-di-O-methoxycarbonylhitachimycin (2), 11, 15-di-O-ethoxycarbonylhitachimycin (3) and 15-O-methoxycarbonylhitachimycin (9) were most effective in in vivo assay.

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