The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
BIOSYNTHETIC SIMILARITY BETWEEN STREPTOMYCES TENJIMARIENSIS AND MICROMONOSPORA OLIVASTEROSPORA WHICH PRODUCE FORTIMICIN-GROUP ANTIBIOTICS
KUNIMOTO HOTTAMOTO MORIOKAYOSHIRO OKAMI
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1989 Volume 42 Issue 5 Pages 745-751

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Abstract
The profile of bioconversion products of istamycin (IS) components by a blocked IS mutant of Streptomyces tenjimariensis that lost IS-productivity suggested a possible biosynthetic pathway of IS similar to that of fortimicin (FT) by Micromonospora olivasterospora. Both organisms are resistant to the antibiotics produced by each other. Based on these similarities, they were examined for their capability to convert an FT-intermediate (FT-B) and IS-intermediates (IS-A0 and -B0) through their biosynthetic pathways. S. tenjimariensis formed 1-epi-FT-B, 2"-N-formimidoyl-FT-A (=dactimicin) and 1-epidactimicin (a new antibiotic) from FT-B. On the other hand, M. olivasterospora converted IS-A0 and -B0 to 2"-N-formimidoyl-IS-A (=IS-A3) and -B (=IS-B3), respectively. Thus, the similarity in antibiotic biosynthesis was confirmed between these FT-group antibiotic-producing organisms. It was also found that the major fermentation product of M. olivasterospora is not FT-A (astromicin) but dactimicin.
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© Japan Antibiotics Research Association
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