ISOLATION OF CB-25-I, AN ANTIFUNGAL ANTIBIOTIC, FROM SERRATIA PLYMUTHICA

JUN'ICHI SHOJI; HIROSHI HINOO; RYUJI SAKAZAKI; TOSHIYUKI KATO; TERUO HATTORI; KOICHI MATSUMOTO; KATSUYA TAWARA; JUNKO KIKUCHI; YOSHIHIRO TERUI

doi:10.7164/antibiotics.42.869

ISOLATION OF CB-25-I, AN ANTIFUNGAL ANTIBIOTIC, FROM SERRATIA PLYMUTHICA

JUN'ICHI SHOJI, HIROSHI HINOO, RYUJI SAKAZAKI, TOSHIYUKI KATO, TERUO HATTORI, KOICHI MATSUMOTO, KATSUYA TAWARA, JUNKO KIKUCHI, YOSHIHIRO TERUI

Author information

JUN'ICHI SHOJI
Shionogi Research Laboratories, Shionogi & Co., Ltd.
HIROSHI HINOO
Shionogi Research Laboratories, Shionogi & Co., Ltd.
RYUJI SAKAZAKI
Shionogi Research Laboratories, Shionogi & Co., Ltd.
TOSHIYUKI KATO
Shionogi Research Laboratories, Shionogi & Co., Ltd.
TERUO HATTORI
Shionogi Research Laboratories, Shionogi & Co., Ltd.
KOICHI MATSUMOTO
Shionogi Research Laboratories, Shionogi & Co., Ltd.
KATSUYA TAWARA
Shionogi Research Laboratories, Shionogi & Co., Ltd.
JUNKO KIKUCHI
Shionogi Research Laboratories, Shionogi & Co., Ltd.
YOSHIHIRO TERUI
Shionogi Research Laboratories, Shionogi & Co., Ltd.

JOURNAL FREE ACCESS

1989 Volume 42 Issue 6 Pages 869-874

DOI https://doi.org/10.7164/antibiotics.42.869

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Abstract

A new antifungal antibiotic, CB-25-I, was isolated from the culture broth of a strain of Senatia plymuthica. The antibiotic, a water-soluble dipeptide, is structurally related to Sch 37137 and A 19009, both produced by strains of Actinomycetales. The antibiotic exhibits inhibitory activity against Candida albicans in YNB medium (a synthetic medium), but the activity is significantly reduced in Sabouroud dextrose medium.

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