KS-501 AND KS-502, NEW INHIBITORS OF Ca2+ AND CALMODULIN-DEPENDENT CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE FROM SPOROTHRIX SP.

SATOSHI NAKANISHI; KATSUHIKO ANDO; ISAO KAWAMOTO; HIROSHI KASE

doi:10.7164/antibiotics.42.1049

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

KS-501 AND KS-502, NEW INHIBITORS OF Ca²⁺ AND CALMODULIN-DEPENDENT CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE FROM SPOROTHRIX SP.

SATOSHI NAKANISHI, KATSUHIKO ANDO, ISAO KAWAMOTO, HIROSHI KASE

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JOURNAL FREE ACCESS

1989 Volume 42 Issue 7 Pages 1049-1055

DOI https://doi.org/10.7164/antibiotics.42.1049

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Abstract

New inhibitors of Ca²⁺ and calmodulin-dependent cyclic-nucleotide phosphodiesterase, KS-501 and KS-502 were isolated from a fungus, Sporothrix sp. KAC-1985. Inhibitory concentration causing 50% inhibition (IC₅₀) values of KS-501 and KS-502 for bovine brain enzyme were 1.8 and 4.3μM, respectively. The compounds exhibited no or weak inhibition for calmodulin-independent cyclic-nucleotide phosphodiesterases and protein kinase C.

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