SYNTHESIS AND IN VITRO ACTIVITY OF NEW SEMI-SYNTHETIC COUMERMYCIN ANALOGS: CHEMICAL MODIFICATION AT THE C-3 AMIDE

Abstract

Several new semi-synthetic coumermycin analogs, which carry a polar substituent at the C-3 amide moiety have been prepared. In vitro antibacterial activity of these new analogs against Gram-positive organisms, particularly methicillin-resistant strains of Staphylococci species has been described.