A NEW AMINOTHIAZOLYLCEPHALOSPORIN HAVING 1-CARBOXYETHOXYIMINO GROUP, ME1228

SEIJI SHIBAHARA; TSUNEO OKONOGI; TAKASHI YOSHIDA; YASUSHI MURAI; TOSHIAKI KUDO; SHIGEHARU INOUYE; SHINICHI KONDO

doi:10.7164/antibiotics.43.62

SEIJI SHIBAHARA, TSUNEO OKONOGI, TAKASHI YOSHIDA, YASUSHI MURAI, TOSHIAKI KUDO, SHIGEHARU INOUYE, SHINICHI KONDO

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JOURNAL FREE ACCESS

1990 Volume 43 Issue 1 Pages 62-69

DOI https://doi.org/10.7164/antibiotics.43.62

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Abstract

Aminothiazolylacetamidocephalosporins having 1-carboxyethoxyimino groups were synthesized and found to have excellent antibacterial activities including anti-pseudomonal activity and low toxicities. Among these cephalosporins, ME1228 having (S)-1-carboxyethoxyimino substituent and being combined with an (N-ethyl-4-pyridinio)thiomethyl group at C-3 showed marked therapeutic effects against systemic infections in mice and was selected as the best candidate for further evaluation.

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