MM 46115, A NEW ANTIVIRAL ANTIBIOTIC FROM ACTINOMADURA PELLETIERI CHARACTERISTICS OF THE PRODUCING CULTURES, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

RAYMOND J. ASHTON; MARTIN D. KENIG; KONG LUK; DONALD N. PLANTEROSE; GILLIAN SCOTT-WOOD

doi:10.7164/antibiotics.43.1387

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

MM 46115, A NEW ANTIVIRAL ANTIBIOTIC FROM ACTINOMADURA PELLETIERI

CHARACTERISTICS OF THE PRODUCING CULTURES, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

RAYMOND J. ASHTON, MARTIN D. KENIG, KONG LUK, DONALD N. PLANTEROSE, GILLIAN SCOTT-WOOD

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JOURNAL FREE ACCESS

1990 Volume 43 Issue 11 Pages 1387-1393

DOI https://doi.org/10.7164/antibiotics.43.1387

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Abstract

Six strains of Actinomadura pelletieri were shown to produce a novel macrolide antibiotic, designated MM 46115. MM 46115 was active against parainfluenza virus 1 and 2 and Grampositive bacteria. Methods are described for the production of MM 46115 by strain IP 729.63, and for the isolation of the compound from a butanol extract of the culture filtrate.

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