SCREENING OF ANTIBIOTICS PREFERENTIALLY ACTIVE AGAINST ras ONCOGENE-EXPRESSED CELLS

KAYOKO SUZUKAKE-TSUCHIYA; YUKARI MORIYA; KATSUHISA YAMAZAKI; MAKOTO HORI; NOBUO HOSOKAWA; TSUTOMU SAWA; HIRONOBU IINUMA; HIROSHI NAGANAWA; CHIAKI IMADA; MASA HAMADA

doi:10.7164/antibiotics.43.1489

SCREENING OF ANTIBIOTICS PREFERENTIALLY ACTIVE AGAINST ras ONCOGENE-EXPRESSED CELLS

KAYOKO SUZUKAKE-TSUCHIYA, YUKARI MORIYA, KATSUHISA YAMAZAKI, MAKOTO HORI, NOBUO HOSOKAWA, TSUTOMU SAWA, HIRONOBU IINUMA, HIROSHI NAGANAWA, CHIAKI IMADA, MASA HAMADA

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JOURNAL FREE ACCESS

1990 Volume 43 Issue 11 Pages 1489-1496

DOI https://doi.org/10.7164/antibiotics.43.1489

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Abstract

During the course of in vitro screening of agents which are preferentially active against ras oncogene-expressed cells, a new anthracycline (identified as 2-demethylsteffimycin D) and a heptaene (possibly a new member of partricins) were isolated from microbial fermentation broths. Among known compounds tested, 5-fluorouracil, 5-fluorodeoxyuridine and oxanosine showed high selectivity towards ras oncogene-expressed cells.

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