A NEW SCREENING METHOD FOR MELANIN BIOSYNTHESIS INHIBITORS USING STREPTOMYCES BIKINIENSIS

KOJI TOMITA; NAHOMI ODA; MASARU OHBAYASHI; HIDEO KAMEI; TAKEO MIYAKI; TOSHIKAZU OKI

doi:10.7164/antibiotics.43.1601

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

A NEW SCREENING METHOD FOR MELANIN BIOSYNTHESIS INHIBITORS USING STREPTOMYCES BIKINIENSIS

KOJI TOMITA, NAHOMI ODA, MASARU OHBAYASHI, HIDEO KAMEI, TAKEO MIYAKI, TOSHIKAZU OKI

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JOURNAL FREE ACCESS

1990 Volume 43 Issue 12 Pages 1601-1605

DOI https://doi.org/10.7164/antibiotics.43.1601

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Abstract

A novel screening method for melanin biosynthesis inhibitors using Streptomyces bikiniensis NRRL B-1049 as the indicator organism has been developed.
Several known compounds, including tyrosinase inhibitors, were found to inhibit melanin production of S. bikiniensis on agar plates. This screening method was applied to fermentation broths of actinomycetes and several cultures with melanin biosynthesis inhibitory activity were found.

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