LL-D49194 ANTIBIOTICS, A NOVEL FAMILY OF ANTITUMOR AGENTS: TAXONOMY, FERMENTATION AND BIOLOGICAL PROPERTIES

Abstract

A novel family of antitumor antibiotics, designated LL-D49194, was isolated from the fermentation broth of an actinomycete strain identified as Streptomyces vinaceus-drappus. LL-D49194 α₁ and β₂ were active against Gram-positive and inactive against Gram-negative bacteria in vitro. The β₁ component was not active against either Gram-positive or Gram-negative bacteria. These antibiotics exhibited significant in vivo activities against several murine tumors, albeit with differing potencies.