TREHALASE INHIBITORS, VALIDOXYLAMINE A AND RELATED COMPOUNDS AS INSECTICIDES

NAOKI ASANO; MASAYOSHI TAKEUCHI; YUKIHIKO KAMEDA; KATSUHIKO MATSUI; YOSHIAKI KONO

doi:10.7164/antibiotics.43.722

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

TREHALASE INHIBITORS, VALIDOXYLAMINE A AND RELATED COMPOUNDS AS INSECTICIDES

NAOKI ASANO, MASAYOSHI TAKEUCHI, YUKIHIKO KAMEDA, KATSUHIKO MATSUI, YOSHIAKI KONO

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JOURNAL FREE ACCESS

1990 Volume 43 Issue 6 Pages 722-726

DOI https://doi.org/10.7164/antibiotics.43.722

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Abstract

Validoxylamine A showed a potent inhibitory activity against insect trehalase in a competitive manner with a Ki value of 4.3 × 10^-10 M. The other validoxylamines and validamycins also exhibited the activity in vitro. Injection of these compounds to young last instar larvae of the tobacco cutworm, Spodoptera litura, elicited the morphological abnormality followed by death after the cessation of feeding. Validoxylamine A showed 100% mortality at a dose of 10 μg/ last instar larva.

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