PRADIMICINS A, B AND C: NEW ANTIFUNGAL ANTIBIOTICS I. TAXONOMY, PRODUCTION, ISOLATION AND PHYSICO-CHEMICAL PROPERTIES

KOJI TOMITA; MAKI NISHIO; KYOICHIRO SAITOH; HARUAKI YAMAMOTO; YUTAKA HOSHINO; HIROAKI OHKUMA; MASATAKA KONISHI; TAKEO MIYAKI; TOSHIKAZU OKI

doi:10.7164/antibiotics.43.755

PRADIMICINS A, B AND C: NEW ANTIFUNGAL ANTIBIOTICS

I. TAXONOMY, PRODUCTION, ISOLATION AND PHYSICO-CHEMICAL PROPERTIES

KOJI TOMITA, MAKI NISHIO, KYOICHIRO SAITOH, HARUAKI YAMAMOTO, YUTAKA HOSHINO, HIROAKI OHKUMA, MASATAKA KONISHI, TAKEO MIYAKI, TOSHIKAZU OKI

Author information

KOJI TOMITA
Bristol-Myers Research Institute, Ltd., Tokyo Research Center
MAKI NISHIO
Bristol-Myers Research Institute, Ltd., Tokyo Research Center
KYOICHIRO SAITOH
Bristol-Myers Research Institute, Ltd., Tokyo Research Center
HARUAKI YAMAMOTO
Bristol-Myers Research Institute, Ltd., Tokyo Research Center
YUTAKA HOSHINO
Bristol-Myers Research Institute, Ltd., Tokyo Research Center
HIROAKI OHKUMA
Bristol-Myers Research Institute, Ltd., Tokyo Research Center
MASATAKA KONISHI
Bristol-Myers Research Institute, Ltd., Tokyo Research Center
TAKEO MIYAKI
Bristol-Myers Research Institute, Ltd., Tokyo Research Center
TOSHIKAZU OKI
Bristol-Myers Research Institute, Ltd., Tokyo Research Center

JOURNAL FREE ACCESS

1990 Volume 43 Issue 7 Pages 755-762

DOI https://doi.org/10.7164/antibiotics.43.755

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Abstract

New antifungal antibiotics, pradimicins A, B and C were isolated from the culture broth of actinomycete strains proposed as Actinomadura hibisca. They are orange to red pigments containing a benzo[a]naphthacenequinone chromophore substituted with a D-alanine, an aminosugar and a D-xylose (pradimicins A and C).

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