MELANOSTATIN, A NEW MELANIN SYNTHESIS INHIBITOR PRODUCTION, ISOLATION, CHEMICAL PROPERTIES, STRUCTURE AND BIOLOGICAL ACTIVITY

YASUMASA ISHIHARA; MASAHISA OKA; MITSUAKI TSUNAKAWA; KOJI TOMITA; MASAMI HATORI; HARUAKI YAMAMOTO; HIDEO KAMEI; TAKEO MIYAKI; MASATAKA KONISHI; TOSHIKAZU OKI

doi:10.7164/antibiotics.44.25

MELANOSTATIN, A NEW MELANIN SYNTHESIS INHIBITOR

PRODUCTION, ISOLATION, CHEMICAL PROPERTIES, STRUCTURE AND BIOLOGICAL ACTIVITY

YASUMASA ISHIHARA, MASAHISA OKA, MITSUAKI TSUNAKAWA, KOJI TOMITA, MASAMI HATORI, HARUAKI YAMAMOTO, HIDEO KAMEI, TAKEO MIYAKI, MASATAKA KONISHI, TOSHIKAZU OKI

Author information

YASUMASA ISHIHARA
Bristol-Myers Squibb Research Institute
MASAHISA OKA
Bristol-Myers Squibb Research Institute
MITSUAKI TSUNAKAWA
Bristol-Myers Squibb Research Institute
KOJI TOMITA
Bristol-Myers Squibb Research Institute
MASAMI HATORI
Bristol-Myers Squibb Research Institute
HARUAKI YAMAMOTO
Bristol-Myers Squibb Research Institute
HIDEO KAMEI
Bristol-Myers Squibb Research Institute
TAKEO MIYAKI
Bristol-Myers Squibb Research Institute
MASATAKA KONISHI
Bristol-Myers Squibb Research Institute
TOSHIKAZU OKI
Bristol-Myers Squibb Research Institute

JOURNAL FREE ACCESS

1991 Volume 44 Issue 1 Pages 25-32

DOI https://doi.org/10.7164/antibiotics.44.25

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Abstract

Melanostatin, a new antibiotic with melanin synthesis inhibitory activity, was isolated from the fermentation broth of Streptomyces clavifer No. N924-2. Its structure was determined by spectral analysis and degradation experiments. Melanostatin strongly inhibited melanin formation in Streptomyces bikiniensis NRRL B-1049 and B16 melanoma cells.

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