L-687, 781, A NEW MEMBER OF THE PAPULACANDIN FAMILY OF β-1, 3-D-GLUCAN SYNTHESIS INHIBITORS I. FERMENTATION, ISOLATION, AND BIOLOGICAL ACTIVITY

FRANK VANMIDDLESWORTH; MARY NALLIN OMSTEAD; DENNIS SCHMATZ; KEN BARTIZAL; ROBERT FROMTLING; GERALD BILLS; KARL NOLLSTADT; SUSAN HONEYCUTT; MARCIA ZWEERINK; GEORGE GARRITY; KEN WILSON

doi:10.7164/antibiotics.44.45

L-687, 781, A NEW MEMBER OF THE PAPULACANDIN FAMILY OF β-1, 3-D-GLUCAN SYNTHESIS INHIBITORS

I. FERMENTATION, ISOLATION, AND BIOLOGICAL ACTIVITY

FRANK VANMIDDLESWORTH, MARY NALLIN OMSTEAD, DENNIS SCHMATZ, KEN BARTIZAL, ROBERT FROMTLING, GERALD BILLS, KARL NOLLSTADT, SUSAN HONEYCUTT, MARCIA ZWEERINK, GEORGE GARRITY, KEN WILSON

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JOURNAL FREE ACCESS

1991 Volume 44 Issue 1 Pages 45-51

DOI https://doi.org/10.7164/antibiotics.44.45

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Abstract

A new β-1, 3-D-glucan synthesis inhibitor, L-687, 781 is produced by the cultivation of Dictyochaeta simplex ATCC 20960. L-687, 781 exhibits potent in vitro antifungal activity as well as anti-Pneumocystis activity in a rat model.

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