Abstract
In the course of our screening for antithrombotic compounds using platelet rich plasma from bovine slaughter blood, 2-methoxy-5-methyl-1, 4-benzoquinone (1) has been isolated from mycelial cultures of Lentinus adhaerens. The compound inhibits the U46619-induced aggregation of human blood platelets with an IC50 of 2.5 μg/ml (16.45 μM) and is a new thromboxane A2 receptor antagonist.
This is the first report on an inhibitor of platelet aggregation derived from secondary metabolism of basidiomycetes.
