CYCLOTHIAZOMYCIN, A NOVEL POLYTHIAZOLE-CONTAINING PEPTIDE WITH RENIN INHIBITORY ACTIVITY TAXONOMY, FERMENTATION, ISOLATION AND PHYSICO-CHEMICAL CHARACTERIZATION

MASAHIRO AOKI; TATSUO OHTSUKA; MASAYOSHI YAMADA; YOSHIKO OHBA; HLROYUKI YOSHIZAKI; HLDEYUKI YASUNO; TAKASHI SANO; JUNKO WATANABE; KAZUTERU YOKOSE; HARUO SETO

doi:10.7164/antibiotics.44.582

CYCLOTHIAZOMYCIN, A NOVEL POLYTHIAZOLE-CONTAINING PEPTIDE WITH RENIN INHIBITORY ACTIVITY

TAXONOMY, FERMENTATION, ISOLATION AND PHYSICO-CHEMICAL CHARACTERIZATION

MASAHIRO AOKI, TATSUO OHTSUKA, MASAYOSHI YAMADA, YOSHIKO OHBA, HLROYUKI YOSHIZAKI, HLDEYUKI YASUNO, TAKASHI SANO, JUNKO WATANABE, KAZUTERU YOKOSE, HARUO SETO

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JOURNAL FREE ACCESS

1991 Volume 44 Issue 6 Pages 582-588

DOI https://doi.org/10.7164/antibiotics.44.582

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Abstract

Cyclothiazomycin is a novel renin inhibitor produced by Streptomyces sp. NR0516. It was isolated from fermentation broth by extraction with butyl alcohol, QAE-Toyopearl column chromatography and preparative HPLC. Cyclothiazomycin, which was determined to be a unique polythiazole-containing bicyclic peptide, exhibited inhibitory activity against human plasma renin with IC₅₀ being 1.7 μM.

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