STRUCTURAL STUDIES ON AVIDINORUBICIN, A NOVEL ANTHRACYCLINE WITH PLATELET AGGREGATION INHIBITORY ACTIVITY

Abstract

Avidinorubicin (MW 1, 214, C₆₀H₈₆N₄O₂₂) was isolated from the cultured broth of strain NR0576 (which was identified as Streptomyces avidinii STAPLEY et al.) by butyl alcohol extraction, Sephadex LH-20 column chromatography and preparative HPLC. Avidinorubicin inhibited thrombin-induced platelet aggregation with an IC₅₀ being 7.9 μM and was determined to be a novel anthracycline possessing two units of a new aminosugar, avidinosamine, in place of two decilonitrose groups in decilorubicin.