FLUVIRUCINS A₁, A₂, B₁, B₂, B₃, B₄ AND B₅, NEW ANTIBIOTICS ACTIVE AGAINST INFLUENZA A VIRUS

II. STRUCTURE DETERMINATION

Abstract

A series of structurally related antiviral antibiotics, fluvirucins A₁, A₂, B₁, B₂, B₃, B₄ and B₅ have been isolated from the fermentation broths of five unidentified actinomycete isolates. Based on spectroscopic analysis, partial degradation experiments and ¹³C-enriched acetic acid-fed biosynthetic studies, their structures were elucidated to be 2, 6, 10-trialkyl-3(or 9)-aminoglycosyl-13-tridecanelactams.