EURYSTATINS A AND B, NEW PROLYL ENDOPEPTIDASE INHIBITORS I. TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL ACTIVITIES

SOICHIRO TODA; YUMIKO OBI; KEI-ICHI NUMATA; YASUTARO HAMAGISHI; KOJI TOMITA; NOBUJIRO KOMIYAMA; CHIKAKO KOTAKE; TAMOTSU FURUMAI; TOSHIKAZU OKI

doi:10.7164/antibiotics.45.1573

EURYSTATINS A AND B, NEW PROLYL ENDOPEPTIDASE INHIBITORS

I. TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL ACTIVITIES

SOICHIRO TODA, YUMIKO OBI, KEI-ICHI NUMATA, YASUTARO HAMAGISHI, KOJI TOMITA, NOBUJIRO KOMIYAMA, CHIKAKO KOTAKE, TAMOTSU FURUMAI, TOSHIKAZU OKI

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JOURNAL FREE ACCESS

1992 Volume 45 Issue 10 Pages 1573-1579

DOI https://doi.org/10.7164/antibiotics.45.1573

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Abstract

Eurystatins A and B, were isolated from the cultured broth of Streptomyces eurythermus R353-21. They showed specific and potent inhibitory activity against prolyl endopeptidase and did not show antimicrobial activity. No lethal toxicity was observed for the two compounds after ip administration in mice at 200 mg/kg.

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