PRODUCTION OF NEW ANTHRACYCLINE ANTIBIOTICS 1-HYDROXY-OXAUNOMYCIN AND 6-DEOXYOXAUNOMYCIN BY LIMITED BIO-SYNTHETIC CONVERSION USING A DAUNORUBICIN-NEGATIVE MUTANT

Abstract

A limited biosynthetic conversion of some known anthracyclinones using a specific daunorubicin-nonproducing mutant provided four new anthracycline antibiotics: 1-Hydroxy-10-methoxycarbonyl-13-deoxocarminomycin; 1-hydroxy-13-deoxocarminomycin; 1-hydroxyoxaunomycin and 6-deoxyoxaunomycin. Their isolation and purification from bioconversion broth, structural determination and antitumor activities against leukemic L1210 cells are described.