QUARTROMICIN, A COMPLEX OF NOVEL ANTIVIRAL ANTIBIOTICS I. PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND ANTIVIRAL ACTIVITY

MITSUAKI TSUNAKAWA; OSAMU TENMYO; KOJI TOMITA; NOBUAKI NARUSE; CHIKAKO KOTAKE; TAKEO MIYAKI; MASATAKA KONISHI; TOSHIKAZU OKI

doi:10.7164/antibiotics.45.180

QUARTROMICIN, A COMPLEX OF NOVEL ANTIVIRAL ANTIBIOTICS

I. PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND ANTIVIRAL ACTIVITY

MITSUAKI TSUNAKAWA, OSAMU TENMYO, KOJI TOMITA, NOBUAKI NARUSE, CHIKAKO KOTAKE, TAKEO MIYAKI, MASATAKA KONISHI, TOSHIKAZU OKI

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JOURNAL FREE ACCESS

1992 Volume 45 Issue 2 Pages 180-188

DOI https://doi.org/10.7164/antibiotics.45.180

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Abstract

A strain of Amycolatopsis orientalis No. Q427-8 (ATCC 53884) was found to produce a complex of new antiviral antibiotics, quartromicin which consisted of at least six components A₁, A₂, A₃, D₁, D₂ and D₃. Structural studies suggested that they are a novel type of molecules unrelated to any known antibiotics. Each component of quartromicin exhibited antiviral activity against herpes simplex virus type 1, influenza virus type A and human immunodeficiency virus.

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