N-ACYL 3-ALKYLIDENYL-AND 3-ALKYL AZETIDIN-2-ONES: A NEW CLASS OF MONOCYCLIC β-LACTAM ANTIBACTERIAL AGENTS 1. STRUCTURE-ACTIVITY RELATIONSHIPS OF 3-ISOPROPYLIDENE AND 3-ISOPROPYL ANALOGS

STEVEN J. BRICKNER; JEFFREY J. GAIKEMA; GARY E. ZURENKO; LAURA J. GREENFIELD; PETER R. MANNINEN; DEBRA A. ULANOWICZ

doi:10.7164/antibiotics.45.213

N-ACYL 3-ALKYLIDENYL-AND 3-ALKYL AZETIDIN-2-ONES: A NEW CLASS OF MONOCYCLIC β-LACTAM ANTIBACTERIAL AGENTS

1. STRUCTURE-ACTIVITY RELATIONSHIPS OF 3-ISOPROPYLIDENE AND 3-ISOPROPYL ANALOGS

STEVEN J. BRICKNER, JEFFREY J. GAIKEMA, GARY E. ZURENKO, LAURA J. GREENFIELD, PETER R. MANNINEN, DEBRA A. ULANOWICZ

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JOURNAL FREE ACCESS

1992 Volume 45 Issue 2 Pages 213-226

DOI https://doi.org/10.7164/antibiotics.45.213

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Abstract

The synthesis and antibacterial activity of a series of N-acyl 3-isopropylidenyl-and 3-isopropyl 2-azetidinones having potent in vitro antibacterial activity, particularly against anaerobic organisms, is described. A distinguishing structural feature of these compounds is the lack of any ionizable moiety appendant to the lactam nitrogen.

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