A NEW TETRACYCLINE ANTIBIOTIC WITH ANTITUMOR ACTIVITY I. TAXONOMY AND FERMENTATION OF THE PRODUCING STRAIN, ISOLATION AND CHARACTERIZATION OF SF2575

MASAHIRO HATSU; TORU SASAKI; HIRO-OMI WATABE; SHINJI MIYADOH; MIEKO NAGASAWA; TAKASHI SHOMURA; MASAJI SEZAKI; SHIGEHARU INOUYE; SHINICHI KONDO

doi:10.7164/antibiotics.45.320

A NEW TETRACYCLINE ANTIBIOTIC WITH ANTITUMOR ACTIVITY

I. TAXONOMY AND FERMENTATION OF THE PRODUCING STRAIN, ISOLATION AND CHARACTERIZATION OF SF2575

MASAHIRO HATSU, TORU SASAKI, HIRO-OMI WATABE, SHINJI MIYADOH, MIEKO NAGASAWA, TAKASHI SHOMURA, MASAJI SEZAKI, SHIGEHARU INOUYE, SHINICHI KONDO

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JOURNAL FREE ACCESS

1992 Volume 45 Issue 3 Pages 320-324

DOI https://doi.org/10.7164/antibiotics.45.320

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Abstract

A new antitumor antibiotic SF2575 has been isolated from a culture filtrate of Streptomyces sp. SF2575. The molecular formula was determined to be C₄₀H₄₃NO₁₅ by elemental analysis, mass and ¹³C NMR spectral analyses. The spectral data revealed SF2575 to be a new tetracycline antibiotic. It was active against Gram-positive bacteria and exhibited antitumor activity against P388 leukemia in mice.

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