CP-82, 009, A POTENT POLYETHER ANTICOCCIDIAL RELATED TO SEPTAMYCIN AND PRODUCED BY Actinomadura sp.

Abstract

A new polyether antibiotic CP-82, 009 (C₄₉H₈₄O₁₇) was isolated by solvent extraction from the fermentation broth of Actinomadura sp. (ATCC 53676). Following purification by column chromatography and crystallization, the structure of CP-82, 009 was elucidated by spectroscopic (NMR and MS) methods. The absolute stereochemistry was determined by a single crystal X-ray analysis of the corresponding rubidium salt. CP-82, 009 is among the most potent anticoccidial agents known, effectively controlling the Eimeria species that are the major causative agents of chicken coccidiosis at doses of 5 nig/kg or less in feed. It is also active in vitro against certain Gram-positive bacteria, as well as the spirochete, Serpulina (Treponema) hyodysenteriae.