The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
SYNTHESIS AND ACTIVITY OF C-21 ALKYLAMINO DERIVATIVES OF (9R)-ERYTHROMYCYLAMINE
PAUL A. LARTEY, SHARI L. DENINNO, RAMIN FAGHIH, DWIGHT J. HARDY, JACOB J. CLEMENT, JACOB J. PLATTNER
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1992 Volume 45 Issue 3 Pages 380-385

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Abstract
Novel analogs of (9R)-9-deoxo-9-(N, N-dimethylamino)erythromycin A bearing N-alkylamino substituents at the C-21 position were synthesized. These compounds retained antibacterial activity. The C-21 N, N-dimethylamino analog showed a modest improvement in activity against some Gram-negative bacteria.
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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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