SCH 42137, A NOVEL ANTIFUNGAL ANTIBIOTIC FROM AN Actinoplanes sp. FERMENTATION, ISOLATION, STRUCTURE AND BIOLOGICAL PROPERTIES

R. COOPER; I. TRUUMEES; I. GUNNARSSON; D. LOEBENBERG; A. HORAN; J. MARQUEZ; M. PATEL; V. GULLO; M. PUAR; P. DAS; S. MITTELMAN

doi:10.7164/antibiotics.45.444

SCH 42137, A NOVEL ANTIFUNGAL ANTIBIOTIC FROM AN Actinoplanes sp.

FERMENTATION, ISOLATION, STRUCTURE AND BIOLOGICAL PROPERTIES

R. COOPER, I. TRUUMEES, I. GUNNARSSON, D. LOEBENBERG, A. HORAN, J. MARQUEZ, M. PATEL, V. GULLO, M. PUAR, P. DAS, S. MITTELMAN

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JOURNAL FREE ACCESS

1992 Volume 45 Issue 4 Pages 444-453

DOI https://doi.org/10.7164/antibiotics.45.444

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Abstract

A novel polycyclic xanthone, Sch 42137, related to the albofungin family of compounds was isolated from culture broth. Its structure was determined by detailed spectroscopic studies and comparison of circular dichroic studies to related compounds albofungin and simaomicin. Sch 42137 exhibited MIC values < 0.125 μg/ml against yeasts and dermatophytes. Details are presented herein.

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