MACROLACTAMS: TWO NOVEL HOMOLOGOUS SERIES OF COMPOUNDS PRODUCED BY Actinomadura sp. SCC 1778

R. COOPER; I. TRUUMEES; R. YARBOROUGH; D. LOEBENBERG; J. MARQUEZ; A. HORAN; M. PATEL; V. GULLO; M. PUAR; B. PRAMANIK

doi:10.7164/antibiotics.45.633

MACROLACTAMS: TWO NOVEL HOMOLOGOUS SERIES OF COMPOUNDS PRODUCED BY Actinomadura sp. SCC 1778

R. COOPER, I. TRUUMEES, R. YARBOROUGH, D. LOEBENBERG, J. MARQUEZ, A. HORAN, M. PATEL, V. GULLO, M. PUAR, B. PRAMANIK

Author information

R. COOPER
Microbial Products, Schering-Plough Research
Present address: Sterling Winthrop Inc.
I. TRUUMEES
Microbial Products, Schering-Plough Research
R. YARBOROUGH
Microbial Products, Schering-Plough Research
D. LOEBENBERG
Microbial Products, Schering-Plough Research
J. MARQUEZ
Microbial Products, Schering-Plough Research
A. HORAN
Microbial Products, Schering-Plough Research
M. PATEL
Microbial Products, Schering-Plough Research
V. GULLO
Microbial Products, Schering-Plough Research
M. PUAR
Molecular Spectroscopy, Schering-Plough Research Institute
B. PRAMANIK
Molecular Spectroscopy, Schering-Plough Research Institute

JOURNAL FREE ACCESS

1992 Volume 45 Issue 5 Pages 633-638

DOI https://doi.org/10.7164/antibiotics.45.633

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Abstract

Eight antifungal compounds were identified from the fermentation of Actinomadura sp. SCC 1778. This culture produces four homologous compounds (C₂₂H₄₂N₂O₅-C₂₅H₄₈N₂O₅) containing the sugar, mycosamine, and four homologous compounds (C₂₂H₄₂N₂O₅-C₂₅H₄₈N₂O₅) containing the sugar, 3, 6-dideoxy-3-amino-L-talopyranose. Five of the compounds identified were novel macrolactams. All these compounds exhibit antifungal activity against Candida spp. with geometric mean MICs ranging from approximately 1.0 μg/ml for the higher homologs to 30 μg/ml for the lower homologs.

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