L-696, 474, A NOVEL CYTOCHALASIN AS AN INHIBITOR OF HIV-1 PROTEASE II. ISOLATION AND STRUCTURE

J. ONDEYKA; O. D. HENSENS; D. ZINK; R. BALL; R. B. LINGHAM; G. BILLS; A. DOMBROWSKI; M. GOETZ

doi:10.7164/antibiotics.45.679

L-696, 474, A NOVEL CYTOCHALASIN AS AN INHIBITOR OF HIV-1 PROTEASE

II. ISOLATION AND STRUCTURE

J. ONDEYKA, O. D. HENSENS, D. ZINK, R. BALL, R. B. LINGHAM, G. BILLS, A. DOMBROWSKI, M. GOETZ

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JOURNAL FREE ACCESS

1992 Volume 45 Issue 5 Pages 679-685

DOI https://doi.org/10.7164/antibiotics.45.679

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Abstract

A novel HIV-1 protease inhibitor, L-696, 474 (C₃₀H₃₉NO₄, 477), was isolated from the fermentations of the fungus Hypoxylon fragiforme (ATCC 20995, MF5511) and purified by silica gel chromatography followed by crystallization. Spectroscopic studies have shown the competitive inhibitor L-696, 474 to be a novel cytochalasin. Two related novel cytochalasins were also isolated and had no effect on the enzyme.

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