WF11605, AN ANTAGONIST OF LEUKOTRIENE B4 PRODUCED BY A FUNGUS II. STRUCTURE DETERMINATION

NOBUHARU SHIGEMATSU; EISAKU TSUJII; NATSUKO KAYAKIRI; SHIGEHIRO TAKASE; HIROKAZU TANAKA; TOSHIJI TADA

doi:10.7164/antibiotics.45.704

WF11605, AN ANTAGONIST OF LEUKOTRIENE B₄ PRODUCED BY A FUNGUS

II. STRUCTURE DETERMINATION

NOBUHARU SHIGEMATSU, EISAKU TSUJII, NATSUKO KAYAKIRI, SHIGEHIRO TAKASE, HIROKAZU TANAKA, TOSHIJI TADA

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JOURNAL FREE ACCESS

1992 Volume 45 Issue 5 Pages 704-708

DOI https://doi.org/10.7164/antibiotics.45.704

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Abstract

The structure of WF11605, a novel tetracyclic triterpene glucoside, was determined to be 1. The plane structure of deacetyl-WF11605 aglycone was elucidated as 2 through the concerted application of a series of 2D NMR techniques. The relative configurations were established by X-ray crystallographic analysis of bis(p-bromobenzoyl) derivative 3 and absolute stereochemistry by CD exciton chirality method.

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