The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
WS9326A, A NOVEL TACHYKININ ANTAGONIST ISOLATED FROM Streptomyces violaceusniger No. 9326
I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES
KENICHI HAYASHIMICHIZANE HASHIMOTONOBUHARU SHIGEMATSUMOTOAKI NISHIKAWAMASAMI EZAKIMICHIO YAMASHITASUMIO KIYOTOMASAKUNI OKUHARAMASANOBU KOHSAKAHIROSHI IMANAKA
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1992 Volume 45 Issue 7 Pages 1055-1063

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Abstract
Data from several studies suggest that tachykinins may play an important role in the pathophysiology of airway diseases, especially asthma. Our aim is to discover tachykinin antagonists which exhibit therapeutically useful anti-asthmatic activity. In our search for activities inhibiting the binding of [3H]substance P to guinea-pig lung membrane preparations, we have found that the fermentation product, WS9326A, isolated from Streptomyces violaceusniger, is a potent tachykinin receptor antagonist.
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© Japan Antibiotics Research Association
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