WS9326A, A NOVEL TACHYKININ ANTAGONIST ISOLATED FROM Streptomyces violaceusniger No. 9326 I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES

KENICHI HAYASHI; MICHIZANE HASHIMOTO; NOBUHARU SHIGEMATSU; MOTOAKI NISHIKAWA; MASAMI EZAKI; MICHIO YAMASHITA; SUMIO KIYOTO; MASAKUNI OKUHARA; MASANOBU KOHSAKA; HIROSHI IMANAKA

doi:10.7164/antibiotics.45.1055

WS9326A, A NOVEL TACHYKININ ANTAGONIST ISOLATED FROM Streptomyces violaceusniger No. 9326

I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES

KENICHI HAYASHI, MICHIZANE HASHIMOTO, NOBUHARU SHIGEMATSU, MOTOAKI NISHIKAWA, MASAMI EZAKI, MICHIO YAMASHITA, SUMIO KIYOTO, MASAKUNI OKUHARA, MASANOBU KOHSAKA, HIROSHI IMANAKA

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JOURNAL FREE ACCESS

1992 Volume 45 Issue 7 Pages 1055-1063

DOI https://doi.org/10.7164/antibiotics.45.1055

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Abstract

Data from several studies suggest that tachykinins may play an important role in the pathophysiology of airway diseases, especially asthma. Our aim is to discover tachykinin antagonists which exhibit therapeutically useful anti-asthmatic activity. In our search for activities inhibiting the binding of [³H]substance P to guinea-pig lung membrane preparations, we have found that the fermentation product, WS9326A, isolated from Streptomyces violaceusniger, is a potent tachykinin receptor antagonist.

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