BUTYROLACTOLS A AND B, NEW ANTIFUNGAL ANTIBIOTICS TAXONOMY, ISOLATION, PHYSICO-CHEMICAL PROPERTIES, STRUCTURE AND BIOLOGICAL ACTIVITY

CHIKAKO KOTAKE; TETSURO YAMASAKI; TOSHIO MORIYAMA; MIEKO SHINODA; NOBUJIRO KOMIYAMA; TAMOTSU FURUMAI; MASATAKA KONISHI; TOSHIKAZU OKI

doi:10.7164/antibiotics.45.1442

BUTYROLACTOLS A AND B, NEW ANTIFUNGAL ANTIBIOTICS

TAXONOMY, ISOLATION, PHYSICO-CHEMICAL PROPERTIES, STRUCTURE AND BIOLOGICAL ACTIVITY

CHIKAKO KOTAKE, TETSURO YAMASAKI, TOSHIO MORIYAMA, MIEKO SHINODA, NOBUJIRO KOMIYAMA, TAMOTSU FURUMAI, MASATAKA KONISHI, TOSHIKAZU OKI

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JOURNAL FREE ACCESS

1992 Volume 45 Issue 9 Pages 1442-1450

DOI https://doi.org/10.7164/antibiotics.45.1442

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Abstract

New antifungal antibiotics, butyrolactols A and B, have been isolated from the culture broth of Streptomyces rochei S785-16. They are novel type of molecules containing a common 2, 3-dihydroxybutyrolactone nucleus substituted with a different long hydroxyalkyl side chain. Butyrolactol A showed good antifungal activity against Aspergillus fumigatus and Trichophyton mentagrophytes, and moderately inhibited the growth of yeasts.

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