The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
CALBISTRINS, NOVEL ANTIFUNGAL AGENTS PRODUCED BY Penicillium restrictum
II. ISOLATION AND ELUCIDATION OF STRUCTURE
GREGORY M. BRILLRANDAL H. CHENRONALD R. RASMUSSENDAVID N. WHITTERNJAMES B. MCALPINE
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JOURNALS FREE ACCESS

1993 Volume 46 Issue 1 Pages 39-47

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Abstract

The novel antifungal agents, calbistrins A, B, C and D have been isolated from a strain of Penicillium restrictum (AB 1875C-28). The four congeners were separated by bioactivity directed fractionation using countercurrent chromatography and preparative-HPLC. NMR studies revealed that the calbistrins each contain a carboxylic acid conjugated tetraene attached through an aliphatic ester linkage to a hexahydronaphthalene system.

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© Japan Antibiotics Research Association
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