NOVEL CYTOCIDAL COMPOUNDS, OXOPROPALINES FROM Streptomyces sp. G324 PRODUCING LAVENDAMYCIN

II. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE ELUCIDATIONS

Abstract

Novel cytocidal compounds designated oxopropalines A, B, D, E and G were isolated from the fermentation of an actinomycete named Streptomyces sp. G324, a strain that also produced an antitumor antibiotic, lavendamycin. All these compounds possessed a β-carboline chromophore. The structures of the oxopropalines were elucidated by several NMR spectral analyses and other spectroscopic experiments.