DEPHOSTATIN, A NOVEL PROTEIN TYROSINE PHOSPHATASE INHIBITOR PRODUCED BY Streptomyces II. STRUCTURE DETERMINATION

HIDEAKI KAKEYA; MASAYA IMOTO; YOSHIKAZU TAKAHASHI; HIROSHI NAGANAWA; TOMIO TAKEUCHI; KAZUO UMEZAWA

doi:10.7164/antibiotics.46.1716

DEPHOSTATIN, A NOVEL PROTEIN TYROSINE PHOSPHATASE INHIBITOR PRODUCED BY Streptomyces

II. STRUCTURE DETERMINATION

HIDEAKI KAKEYA, MASAYA IMOTO, YOSHIKAZU TAKAHASHI, HIROSHI NAGANAWA, TOMIO TAKEUCHI, KAZUO UMEZAWA

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JOURNAL FREE ACCESS

1993 Volume 46 Issue 11 Pages 1716-1719

DOI https://doi.org/10.7164/antibiotics.46.1716

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Abstract

Dephostatin, a novel tyrosine phosphatase inhibitor, was isolated from the culture broth of Streptomyces sp. MJ742-NF5. The structure was elucidated to be 2-(N-methyl-N-nitroso)hydroquinone by spectral and chemical analyses of dephostatin and its derivatives.

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