SYNTHESES OF THE POTENT INHIBITORS OF NEURAMINIDASE, N-(1, 2-DIHYDROXYPROPYL) DERIVATIVES OF SIASTATIN B AND ITS 4-DEOXY ANALOGS

Abstract

Potent inhibitors of neuraminidase, 3, 4-didehydro-4-deoxysiastatin B, 4-deoxysiastatin B and N-[(S and R)-1, 2-dmydroxypropyl] derivatives of siastatin B, 3, 4-didehydro-4-deoxysiastatin B and 4-deoxysiastatin B have been synthesized by the chemical modifications of siastatin B.