BENASTATINS C AND D, NEW INHIBITORS OF GLUTATHIONE S-TRANSFERASE, PRODUCED BY Streptomyces sp. MI384-DF12 PRODUCTION, ISOLATION, STRUCTURE DETERMINATION AND BIOLOGICAL ACTIVITIES

TAKAYUKI AOYAMA; FUKIKO KOJIMA; TADAO YAMAZAK; TOCHIRO TATEE; FUMINORI ABE; YASUHIKO MURAOKA; HIROSHI NAGANAWA; TAKAAKI AOYAG; TOMIO TAKEUCHI

doi:10.7164/antibiotics.46.712

BENASTATINS C AND D, NEW INHIBITORS OF GLUTATHIONE S-TRANSFERASE, PRODUCED BY Streptomyces sp. MI384-DF12

PRODUCTION, ISOLATION, STRUCTURE DETERMINATION AND BIOLOGICAL ACTIVITIES

TAKAYUKI AOYAMA, FUKIKO KOJIMA, TADAO YAMAZAK, TOCHIRO TATEE, FUMINORI ABE, YASUHIKO MURAOKA, HIROSHI NAGANAWA, TAKAAKI AOYAG, TOMIO TAKEUCHI

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JOURNAL FREE ACCESS

1993 Volume 46 Issue 5 Pages 712-718

DOI https://doi.org/10.7164/antibiotics.46.712

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Abstract

Benastatin C, a new member of the benastatins, has been isolated from the culture broth of Streptomyces sp. MI384-DF12. The structure of benastatin C was elucidated as 2-decarboxybenastatin A by NMR studies. Benastatin D, 2-decarboxybenastatin B, was derived from benastatin B. Benastatins C and D showed inhibitory activities against human pi class glutathione S-transferase (GST π) and excellent stimulatory activities on the murine lymphocyte blastogenesis in vitro.

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