The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
LEPTOLSTATIN FROM Streptomyces sp. SAM 1595, A NEW GAP PHASE-SPECIFIC INHIBITOR OF THE MAMMALIAN CELL CYCLE
II. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE
KEIICHI ABEMINORU YOSHIDAHIDEO NAOKSUEHARU HORINOUCHITERUHIKO BEPPU
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1993 Volume 46 Issue 5 Pages 735-740

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Abstract
Leptolstatin, a product from Streptomyces sp. SAM 1595, is a gap phase-specific inhibitor of the mammalian cell cycle. Physico-chemical properties and spectrometric analyses showed that the structure of leptolstatin is (2Z, 6E, 8Z, 12E, 14E, 22E)-19, 24-dihydroxy-8, 10, 14, 16, 18, 20, 22-heptamethyl-17-oxo-2, 6, 8, 12, 14, 22-tetracosahexaen-5-olide.
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© Japan Antibiotics Research Association
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