UK-1, A NOVEL CYTOTOXIC METABOLITE FROM Streptomyces sp. 517-02 I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

MASASHI UEKI; KEIICHI UENO; SHINJI MIYADOH; KEIICHI ABE; KOZO SHIBATA; MAKOTO TANIGUCHI; SUSUMU OI

doi:10.7164/antibiotics.46.1089

UK-1, A NOVEL CYTOTOXIC METABOLITE FROM Streptomyces sp. 517-02

I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

MASASHI UEKI, KEIICHI UENO, SHINJI MIYADOH, KEIICHI ABE, KOZO SHIBATA, MAKOTO TANIGUCHI, SUSUMU OI

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JOURNAL FREE ACCESS

1993 Volume 46 Issue 7 Pages 1089-1094

DOI https://doi.org/10.7164/antibiotics.46.1089

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Abstract

A new benzoxazole, UK-1, was isolated from the mycelial cake of an actinomycete strain 517-02. Based on morphological, cultural and physiological characteristics, strain 517-02 was seemed to be a close relative of Streptomyces morookaense. UK-1 showed potent cytotoxic activity against B16, HeLa and P388 cells and did not show any antimicrobial activity.

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